Six of 7 sheep sustained AFL for 28 days. Sheep were monitored for spontaneous conversion of AFL to AF. AFL was induced in 7 animals, and 4 remained in sinus rhythm (controls). We investigated the electrophysiological consequences of chronic AFL using an ovine anatomic right atrial Y-lesion model. Lin is an employee of Sanofi-Aventis, Bridgewater, New Jersey.Atrial flutter (AFL) and atrial fibrillation (AF) frequently coexist, yet the specific relationship between these arrhythmias, and particularly whether sustained AFL leads to AF, is unknown. Varker are employees in the Healthcare Division of Thomson Reuters, which has a research consulting agreement with Sanofi-Aventis. Paul, Minnesota Paracor Medical, Sunnyvale, California AstraZeneca, Wilmington, Delaware and Otsuka Pharmaceutical Inc., Princeton, New Jersey. Naccarelli received research support from Boston Scientific, Boston, Massachusetts Medtronic, Minneapolis, Minnesota Sanofi-Aventis, Bridgewater, New Jersey Boehringer-Ingelheim, Ingelheim, Germany ARYx, Fremont, California and GlaxoSmithKline, Research Triangle Park, North Carolina and is a consultant to GlaxoSmithKline Medtronic, Minneapolis, Minnesota Boston Scientific, Boston, Massachusetts Pfizer, New York, New York Xention, Cambridge, United Kingdom Sanofi-Aventis, Bridgewater, New Jersey Wyeth Pharmaceuticals, Collegeville, Pennsylvania Novartis, New York, New York Astellas Pharma US, Deerfield, Illinois Cardiome, Vancouver, British Columbia, Canada CV Therapeutics, Palo Alto, California Transoma Medical, St. This study was supported by Sanofi-Aventis, Bridgewater, New Jersey. The current and projected increases in the prevalence of AF are greater than predictedīy a previous sentinel study and might reflect more than the aging of the population. Prevalence of AF and AFL is high and is projected to increase considerably by 2050. The projected prevalence for 2050 was 7.56 million for AF only,Ġ.15 million for AFL only, and 0.44 million for AF and AFL. In the United States had AF only, 0.07 million had AFL only, and 0.19 million hadĪF and AFL in 2005. Rates for AF and/or AFL in the databases, it was estimated that 3.03 million persons
Applying the US Census Bureau population estimates to the prevalence (62.0%, 61.3%, and 57.0%, respectively) and coronary artery disease (43.0%, 44.7%,Īnd 44.5%, respectively), than matched controls (45.1% hypertension and 19.4% coronaryĪrtery disease).
Patients with AF only, AFL only, and AF andĪFL had a greater (p <0.001) prevalence of co-morbidities, including hypertension Were used to identify patients aged ≥20 years with nontransient AF and/or AFL andĪge- and gender-matched controls without these conditions. Claims data drawn from JulyĢ004 to December 2005 from the MarketScan research databases from Thomson Reuters In the United States using a large national database. Study estimated the current and projected prevalence of AF and atrial flutter (AFL) The prevalence data for atrial fibrillation (AF) are dated.